Acta Crystallographica Section A

Foundations of Crystallography

Volume 57, Part 4 (July 2001)

research papers

Acta Cryst. (2001). A57, 414-419 [ doi:10.1107/S0108767301002720 ]

The method of joint probability distribution functions applied to MAD techniques. The centric case

C. Giacovazzo and D. Siliqi

Abstract: Traditional probabilistic approaches consider MAD (multiple-wavelength anomalous-dispersion) data as a special MIR (multiple isomorphous replacement) case. The rigorous method of the joint probability distribution functions has been applied to solve the phase problem, with the assumption that the anomalous scatterers' substructure is a priori known. The probabilistic approach is able to handle measurement errors: it has been applied to symmetry-restricted phases and provides simple and efficient formulas.

Keywords: joint probability distribution functions; multiple-wavelength anomalous dispersion (MAD); multiple isomorphous replacement (MIR).