Journal of Applied Crystallography

Volume 39, Part 6 (December 2006)


laboratory notes



J. Appl. Cryst. (2006). 39, 922-924    [ doi:10.1107/S0021889806040921 ]

An automated platform for parallel crystallization of small organic molecules

A. J. Florence, A. Johnston, P. Fernandes, N. Shankland and K. Shankland

Abstract: An automated platform for parallel crystallization of small organic molecules from solution is described. The principal gain over manual crystallization lies in the automated sequencing of crystallization steps, including computer-controlled dosing of liquids and solids. The platform is designed to conduct 32 crystallizations per day, from solution volumes up to 10 ml, allowing a search for physical forms to be conducted over a finer grid than might be accessible manually and thereby increasing the probability of success.

Keywords: polymorph screening; crystallization; automation; solvates; powder diffraction.

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